Important Safety Information for
DUAC Topical Gel

DUAC Topical Gel contains the antibiotic clindamycin. You should not use DUAC Topical Gel if you: are allergic to benzoyl peroxide or the antibiotics clindamycin or lincomycin, have Crohn’s disease, have ulcerative colitis, or have developed inflammation of the colon (colitis) with past antibiotic use.
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Risks and Side Effects


DUAC Topical Gel is a prescription medicine used on the skin to treat inflammatory acne. DUAC Topical Gel has not been shown to have any additional benefit than benzoyl peroxide alone in the treatment of non-inflammatory acne.

It is not known if DUAC Topical Gel is safe or effective in children under 12 years of age.

You should not use DUAC Topical Gel if you:

  • Are allergic to benzoyl peroxide, the antibiotics clindamycin or lincomycin, or any of the inactive ingredients
  • Have Crohn’s disease
  • Have ulcerative colitis
  • Have developed inflammation of the colon (colitis) with past antibiotic use

Clindamycin taken orally or through IV may result in severe colitis, which may result in death. When you apply DUAC Topical Gel to your skin, some of the antibiotic clindamycin is absorbed through the skin and reaches your bloodstream. This may result in diarrhea. If you experience severe diarrhea, stop DUAC Topical Gel and call your doctor immediately.

DUAC Topical Gel is for skin use only; avoid contact with the eyes and mucous membranes. If you use DUAC Topical Gel with other topical acne medications, skin irritation may result.

Antibiotics may result in an overgrowth of bacteria and other living organisms. If you develop a yeast infection, stop using DUAC Topical Gel and call your doctor.

Tell your doctor:

  • If you are pregnant or planning to become pregnant. It is not known if DUAC Topical Gel may harm your unborn baby.
  • If you are breastfeeding. DUAC Topical Gel may pass through your milk and may harm your baby.

What You Should Know About Using DUAC Topical Gel with Other Medications:

Because clindamycin and erythromycin work against each other, do not use products containing these antibiotics at the same time.

Always talk to your healthcare provider before starting any new medications.


How Do I Use DUAC Topical Gel?

  • Use only as directed by your healthcare provider.
  • Apply once daily in the evening or as directed by your healthcare provider to affected areas after the skin is gently washed, rinsed with warm water, and patted dry.
  • Do not get in your eyes or inside your nose or mouth.
  • Do not use for any condition other than inflammatory acne.
  • Do not use any other topical acne medicine unless your healthcare provider tells you to do so.
  • DUAC Topical Gel may bleach your hair or colored fabrics.
  • Avoid long periods of time in sunlight. Wear a hat or other clothing to decrease your exposure to the sun.

DUAC Topical Gel may cause serious side effects, including:

  • Inflammation of the colon (colitis). Clindamycin, one of the ingredients in DUAC Topical Gel, can cause severe colitis that may lead to death. Stop using DUAC Topical Gel and call your doctor if you develop severe watery diarrhea, or bloody diarrhea.

The Most Common Side Effects Are:

  • In medical studies, side effects with DUAC Topical Gel were generally limited to the skin and included peeling, dryness, burning, and/or redness.
  • Anaphylaxis, a severe allergic reaction, as well as allergic reactions leading to hospitalization, has been reported with use of DUAC Topical Gel.
  • This listing of side effects is not complete. Your healthcare provider can discuss with you a more complete list of side effects that may occur when using DUAC Topical Gel.

Important Safety Information for DUAC Topical Gel

DUAC Topical Gel contains the antibiotic clindamycin. You should not use DUAC Topical Gel if you: are allergic to benzoyl peroxide or the antibiotics clindamycin or lincomycin, have Crohn’s disease, have ulcerative colitis, or have developed inflammation of the colon (colitis) with past antibiotic use.

Clindamycin taken orally or through IV may result in severe colitis, which may result in death. Topical clindamycin has been shown to be absorbed through the skin and may reach the bloodstream. Diarrhea, bloody diarrhea, and colitis have been reported with the use of topical clindamycin. If you experience any of these signs, stop DUAC Topical Gel and call your doctor immediately.

DUAC Topical Gel is for skin use only; avoid contact with the eyes and mucous membranes. If you use DUAC Topical Gel with other topical acne medications, skin irritation may result.

Antibiotics may result in an overgrowth of bacteria and other living organisms. If you develop a yeast infection, stop using DUAC Topical Gel and call your doctor.

DUAC Topical Gel should not be used with products that contain erythromycin. Tell your doctor if you take medicine containing erythromycin.

Tell your doctor if you are pregnant or plan to become pregnant, as it is not known if DUAC Topical Gel may harm your unborn baby.

It is not known if DUAC Topical Gel passes into breast milk. Topical clindamycin may be absorbed through the skin into the bloodstream. Clindamycin may pass into the breast milk when taken by mouth or by injection. You and your doctor should decide if you will use DUAC Topical Gel or breast-feed.

It is not known if DUAC Topical Gel is safe or effective in children under 12 years of age.

In medical studies, side effects of DUAC Topical Gel were generally limited to the skin and included peeling, dryness, burning, and/or redness.

If you develop allergic symptoms such as severe swelling or shortness of breath, you should stop using DUAC Topical Gel and contact your doctor immediately.

DUAC Topical Gel may bleach hair and colored fabrics.

Avoid long periods of time in sunlight. Always wear sunscreen and wear a hat or other clothing to decrease your exposure to the sun.

For more information about DUAC Topical Gel, read the Full Prescribing Information.